Article
Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure.
Molecular carcinogenesis - 1 Jun 1995
Ghebranious N, Knoll B J, Wu H, Lozano G, Sell S
Abstract excerpt
A mutation in the tumor suppressor p53 gene resulting in an Arg-->Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure. To determine the significance of this mutation in an in vivo experimental model using transgenic mice, we introduced a two-nucleotide change in the mouse p53 gene at amino-acid position 246,...
Topics
- Aflatoxin B1
- Amino Acid Sequence
- Animals
- Arginine
- Base Sequence
- Carcinoma, Hepatocellular
- Codon
- Creatine Kinase
- Genes, p53
- Hepatitis B
- Humans