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Article

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

Molecular and cellular biology - 1 Jan 1991

Milner J, Medcalf E A, Cook A C

Abstract excerpt

It has been suggested that the dominant effect of mutant p53 on tumor progression may reflect the mutant protein binding to wild-type p53, with inactivation of suppressor function. To date, evidence for wild-type/mutant p53 complexes involves p53 from different species. To investigate wild-type/m...

Topics

Animals
Antibodies, Monoclonal
Blotting, Western
Cloning, Molecular
Genes, Tumor Suppressor
Humans
Macromolecular Substances
Mice
Mutation
Precipitin Tests
Protein Binding
Species Specificity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Structure-Activity Relationship

Transfection

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 1986215
DOI: 10.1128/mcb.11.1.12-19.1991
PMCID: PMC359578

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1986215-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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