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Article

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

Molecular and cellular biology - 1 Jan 1991

Milner J, Medcalf E A, Cook A C

Abstract excerpt

It has been suggested that the dominant effect of mutant p53 on tumor progression may reflect the mutant protein binding to wild-type p53, with inactivation of suppressor function. To date, evidence for wild-type/mutant p53 complexes involves p53 from different species. To investigate wild-type/mutant p53 complexes in relation to natural tumor progression, we sought to identify intraspecific complexes, using...

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Identifiers

PMID: 1986215
DOI: 10.1128/mcb.11.1.12-19.1991
PMCID: PMC359578

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Source receipt: pubmed, retrieved 7 Sept 2026.

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