Article
Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation.
Hepatology (Baltimore, Md.) - 1 Oct 1995
Dumenco L, Oguey D, Wu J, Messier N, Fausto N
Abstract excerpt
The p53 gene is frequently mutated in human tumors; in hepatocellular carcinomas, there is a high frequency of a specific mutation at codon 249 in regions with significant aflatoxin exposure. To assess the role of this p53 mutation in the development of hepatocellular carcinoma, a mutant murine p...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Blotting, Western
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Codon
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry
- Liver
- Liver Neoplasms, Experimental
- Mice
- Molecular Sequence Data
- Mutation
- Transfection