Article
p53 mutants with changes in conserved region II: three classes with differing antibody reactivity, SV40 T antigen binding and ability to inhibit transformation of rat cells.
Oncogene - 1 Aug 1993
Schmieg F I, Simmons D T
Abstract excerpt
The wild-type p53 gene is able to inhibit the ability of a number of oncogenes to induce transformation, but this inhibition is frequently lost when the p53 gene undergoes mutation. In this study, we generated mutated mouse p53 proteins containing conservative amino acid substitutions at residues...
Topics
- Adenovirus E1A Proteins
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Cell Transformation, Neoplastic
- Conserved Sequence
- Genes, p53
- Genes, ras
- Mice
- Mutation
- Rats
- Simian virus 40