Article
Hepatocellular carcinoma p53 G > T transversions at codon 249: the fingerprint of aflatoxin exposure?
Environmental health perspectives - 1 Apr 1997
Lasky T, Magder L
Abstract excerpt
The molecular epidemiology of p53 mutations allows the possibility of correlating particular mutations with specific environmental carcinogens and establishing one step in the causal pathway between exposure to carcinogens and the development of cancer. A striking example is the G > T transversion at the third base pair of codon 249 observed in liver cancer patients possibly exposed to high levels of aflatoxins...
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