Article
An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico.
Carcinogenesis - 1 May 1996
Soini Y, Chia S C, Bennett W P, Groopman J D, Wang J S, DeBenedetti V M, Cawley H, Welsh J A, Hansen C, Bergasa N V, Jones E A, DiBisceglie A M, Trivers G E, Sandoval C A, Calderon I E, Munoz Espinosa L E, Harris C C
Abstract excerpt
The p53 tumor suppressor gene is commonly mutated in human hepatocellular carcinoma (HCC). The most frequent mutation in HCC in populations exposed to a high dietary intake of aflatoxin B1 (AFB1) is an AGGarg-->AGTser missense mutation in codon 249 of the p53 gene. We analyzed HCCs from Monterrey, Mexico, for the codon 249ser hotspot mutation. We also analyzed the serum AFB1-albumin adduct levels of the donors...
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