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Article

p53 mutation in hepatocellular carcinoma after aflatoxin exposure.

Lancet (London, England) - 30 Nov 1991

Ozturk M

Abstract excerpt

Mutations of the p53 gene are found in hepatocellular carcinoma (HCC), the most common form of primary liver cancer. Specific mutations might reflect exposure to specific carcinogens and we have screened HCC samples from patients in 14 different countries to determine the frequency of a hotspot mutation at codon 249 of the tumour suppressor p53 gene. We detected mutations in 17% of tumours (12/72) from four...

Topics

Adult
Aflatoxins
Carcinoma, Hepatocellular
Codon
Genes, p53
Humans
Incidence
Liver Neoplasms
Male
Middle Aged
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1682737
DOI: 10.1016/0140-6736(91)92236-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1682737-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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