Article
Effects of the TP53 p.R249S mutant on proliferation and clonogenic properties in human hepatocellular carcinoma cell lines: interaction with hepatitis B virus X protein.
Carcinogenesis - 1 Aug 2010
Gouas Doriane A, Shi Hong, Hautefeuille Agnès H, Ortiz-Cuaran Sandra L, Legros Pénélope C, Szymanska Katarzyna J, Galy Olivier, Egevad Lars A, Abedi-Ardekani Behnoush, Wiman Klas G, Hantz Olivier, Caron de Fromentel Claude, Chemin Isabelle A, Hainaut Pierre L
Abstract excerpt
Aflatoxin B(1) (AFB(1)) is a risk factor for hepatocellular carcinoma (HCC) in many low-resource countries. Although its metabolites bind at several positions in TP53, a mutation at codon 249 (AGG to AGT, arginine to serine, p.R249S) accounts for 90% of TP53 mutations in AFB(1)-related HCC. This specificity suggests that p.R249S confers a selective advantage during hepatocarcinogenesis. Using HCC cell lines, we...
Topics
- Aflatoxin B1
- Africa, Western
- Asia, Southeastern
- Carcinoma, Hepatocellular
- Cell Division
- Cell Line, Tumor
- DNA Primers
- Gene Silencing
- Humans