Article
Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma.
The American journal of surgical pathology - 1 Dec 1993
Goldblum J R, Bartos R E, Carr K A, Frank T S
Abstract excerpt
In areas of the world where hepatitis B and aflatoxin ingestion are common, alterations of the p53 tumor suppressor gene have frequently been reported in hepatocellular carcinoma (HCC). In particular, G-to-T transversions at codon 249 of the p53 gene have been consistently observed in hepatocellular carcinomas in China and sub-Saharan Africa. The goal of this study was to determine the frequency and relationship...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Carcinoma, Hepatocellular
- Child
- Child, Preschool
- Codon
- DNA, Viral
- Female
- Gene Amplification