Article
Hepatitis B and alterations of the p53 tumor suppressor gene in hepatocellular carcinoma.
The American journal of surgical pathology - 1 Dec 1993
Goldblum J R, Bartos R E, Carr K A, Frank T S
Abstract excerpt
In areas of the world where hepatitis B and aflatoxin ingestion are common, alterations of the p53 tumor suppressor gene have frequently been reported in hepatocellular carcinoma (HCC). In particular, G-to-T transversions at codon 249 of the p53 gene have been consistently observed in hepatocellular carcinomas in China and sub-Saharan Africa. The goal of this study was to determine the frequency and relationship...
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