Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.

doi:10.1007/978-3-319-20819-0_12

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Article

Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion.

Results and problems in cell differentiation - 1 Jan 2015

Lanning Dennis K, Knight Katherine L

Abstract excerpt

Gene conversion, mediated by activation-induced cytidine deaminase (AID), has been found to contribute to generation of the primary antibody repertoire in several vertebrate species. Generation of the primary antibody repertoire by gene conversion of immunoglobulin (Ig) genes occurs primarily in gut-associated lymphoid tissues (GALT) and is best described in chicken and rabbit. Here, we discuss current knowledge...

Topics

Animals
Antibody Diversity
Chickens
Cytidine Deaminase
Gastrointestinal Tract
Gene Conversion
Genes, Immunoglobulin
Genetic Variation
Host-Pathogen Interactions
Humans
Lymphoid Tissue
Mice
Microbiota
Rabbits
Species Specificity
AICDA (Activation-Induced Cytidine Deaminase)

Source

Open in PubMed

Identifiers

PMID: 26537386
DOI: 10.1007/978-3-319-20819-0_12

Genes

GALT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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