TP53 gene mutations and protein accumulation in primary vaginal carcinomas.

doi:10.1038/bjc.1995.288

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Article

TP53 gene mutations and protein accumulation in primary vaginal carcinomas.

British journal of cancer - 1 Jul 1995

Skomedal H, Kristensen G, Helland A, Nesland J M, Kooi S, Børresen A L, Holm R

Abstract excerpt

Primary carcinomas from 46 patients were screened for TP53 alterations. Immunohistochemistry demonstrated nuclear TP53 protein accumulation in 22 (48%) cases using the polyclonal CM1 antiserum, whereas 15 (33%) cases showed positive nuclear staining with the mononuclear antibody PAb 1801. Constan...

Topics

Adult
Aged
Aged, 80 and over
DNA, Viral
Female
Humans
Immunohistochemistry
Middle Aged
Mutation
Papillomaviridae
Tumor Suppressor Protein p53
Vaginal Neoplasms

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