Article
Soluble protein but not peptide administration diverts the immune response of a clonal CD4+ T cell population to the T helper 2 cell pathway.
Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 1996
Degermann S, Pria E, Adorini L
Abstract excerpt
BALB/c mice immunized with protein Ags such as OVA in adjuvant mount a Th1-type response. Inhibition of Th1 and development of Th2 cells can be induced by pretreating BALB/c mice with soluble OVA before priming. To investigate some aspects of this immune deviation in vivo, naive TCR transgenic T...
Topics
- Adoptive Transfer
- Animals
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Chickens
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Transgenic
- Ovalbumin
- Peptide Fragments
- Peptides
- Phenotype
- Proteins
- Receptors, Antigen, T-Cell
- Solubility
- Th1 Cells
- Th2 Cells