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Article

The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.

International immunology - 1 Dec 2004

Tamura Toshiki, Ariga Haruyuki, Kinashi Tatsuo, Uehara Shuichiro, Kikuchi Takeshi, Nakada Makiyo, Tokunaga Takeshi, Xu Wen, Kariyone Ai, Saito Takashi, Kitamura Toshio, Maxwell Gavin, Takaki Satoshi, Takatsu Kiyoshi

Abstract excerpt

CD4+ Th1 cells play a critical role in the induction of cell-mediated immune responses that are important for the eradication of intracellular pathogens. Peptide-25 is the major Th1 epitope for Ag85B of Mycobacterium tuberculosis and is immunogenic in I-Ab mice. To elucidate the role of the TCR and IFN-gamma/IL-12 signals in Th1 induction, we generated TCR transgenic mice (P25 TCR-Tg) expressing TCR alpha- and...

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Share to Antigen-Presenting Cells
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Interleukin-12

Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 15477229
DOI: 10.1093/intimm/dxh170

Genes

STAT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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