Article
Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ T cells.
Immunology - 1 Dec 2002
Firpo Eduardo J, Kong Raymond K, Zhou Qinghong, Rudensky Alexander Y, Roberts James M, Franza B Robert
Abstract excerpt
The transgenic T-cell receptor in mouse TEa CD4+ lymphocytes recognizes an endogenous peptide, Ealpha52-68, presented in the context of the major histocompatibility complex class II molecule I-Ab. In response to an optimal peptide concentration TEa cells enter the cell cycle and proliferate. However, a single exposure to high doses of the specific peptide diminished cell expansion upon subsequent restimulation....
Topics
- Animals
- CD4 Antigens
- Cell Cycle Proteins
- Cell Division
- Clonal Anergy
- Cyclin-Dependent Kinase Inhibitor p27
- Dose-Response Relationship, Immunologic
- Enzyme Inhibitors
- Epitopes
- Flow Cytometry
- Interleukin-2
- Interphase
- Male