Article
The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen.
International immunology - 1 Apr 2006
Yang C-P, Sparshott S M, Duffy D, Garside P, Bell E B
Abstract excerpt
Naive and primed/memory CD4 T cells are distinguished by changes in the expression of activation/adhesion molecules that correspond with an altered function. Adoptively transferred TCR transgenic (tg) CD4 T cells specific for ovalbumin peptide (OVA-pep) were analysed for changing phenotype and the speed of change in vivo following antigen challenge with alum-precipitated (ap) OVA-pep, a conjugate that stimulated...
Topics
- Animals
- Antigens
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD4-Positive T-Lymphocytes
- Cell Survival
- Hyaluronan Receptors
- Immunologic Memory
- Integrin alpha4
- L-Selectin
- Lectins, C-Type
- Leukocyte Common Antigens
- Lymphocyte Activation
- Mice