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Article

Site of antigen delivery can influence T cell priming: pulmonary environment promotes preferential Th2-type differentiation

1 Mar 2000

Abstract excerpt

Delivery of foreign antigens to mucosal surfaces, such as the pulmonary airways, has been shown to preferentially induce Th2-mediated responses in humans and in mice. What is not clear from these studies is whether this preferential skewing in responses is the result of the limited types of antigen being administered and/or a bias towards using particular genetic strains of mice, or whether the lung environment...

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PMID: 10741400
DOI: 10.1002/1521-4141(200003)30:3<840::aid-immu840>3.0.co;2-l

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