Article
Increased susceptibility of fas mutant MRL-lpr/lpr mice to staphylococcal enterotoxin B-induced septic shock.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1995
Mountz J D, Baker T J, Borcherding D R, Bluethmann H, Zhou T, Edwards C K
Abstract excerpt
MRL-lpr/lpr mice are defective in the fas Ag/APO-1 apoptosis gene (CD95). Using the hepatotoxin D-galactosamine (D-GalNH2), we demonstrate that MRL-lpr/lpr mice have an increased susceptibility to staphylococcal enterotoxin B (SEB)-induced lethal shock, which causes them to exhibit the septic shock-like behaviors of fur ruffling and listlessness, and death occurs within 8 to 18 h. SEB susceptibility is greater in...
Topics
- Animals
- Enterotoxins
- Histocompatibility Antigens Class II
- Mice
- Mice, Knockout
- Mice, Mutant Strains
- Mice, Transgenic
- Mutation
- Receptors, Antigen, T-Cell
- Shock, Septic
- Staphylococcus