Article
A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1995
Cullen C M, Bonventre P F, Heeg H, Bluethmann H, Mountz J D, Edwards C K
Abstract excerpt
Recombinant toxic shock syndrome toxin-1 (rTSST-1) administered to MRL-lpr/lpr TCR V beta 8.2 transgenic mice at doses of 0.1 microgram/mouse resulted in 100% mortality. This was an unexpected finding since TSST-1 does not activate V beta 8.2 T cells. In contrast, control mice heterozygous at the...
Topics
- Adenine
- Animals
- Bacterial Toxins
- Base Sequence
- Cells, Cultured
- Cyclosporine
- Enterotoxins
- Female
- Heterozygote
- Interleukin-2
- Interleukin-6
- Isoquinolines
- Lipopolysaccharides
- Liver
- Lymphocyte Activation
- Mice
- Mice, Transgenic
- Molecular Sequence Data