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Article

Vasculitis-susceptible genes in mice with a deficit in Fas-mediated apoptosis.

International journal of cardiology - 1 Oct 1998

Nose M, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Mori S, Nishimura M, Wang Y, Kamoto T, Hiai H

Abstract excerpt

Autoimmune diseases show complex pathological manifestations, which frequently involve systemic vasculitis. This complication is understood to be a manifestation of advanced disease, or to represent distinct entities, restricted by genetic and/or environmental factors. An MRL/Mp strain of mice bearing the Fas deletion mutant gene, lpr (MRL/lpr), spontaneously develop systemic vasculitis coincidentally with...

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PMID: 9951801
DOI: 10.1016/s0167-5273(98)00146-6

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