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Article

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2000

Josephs M D, Bahjat F R, Fukuzuka K, Ksontini R, Solorzano C C, Edwards C K, Tannahill C L, MacKay S L, Copeland E M, Moldawer L L

Abstract excerpt

Tumor necrosis factor (TNF)-alpha and Fas ligand (FasL) are trimeric proteins that induce apoptosis through similar caspase-dependent pathways. Hepatocytes are particularly sensitive to inflammation-induced programmed cell death, although the contribution of TNF-alpha and/or FasL to this injury response is still unclear. Here, we report that D-galactosamine and lipopolysaccharide-induced liver injury in C57BL/6...

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Source

Identifiers

PMID: 10801287
DOI: 10.1152/ajpregu.2000.278.5.R1196

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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