Apoptosis defects analyzed in TcR transgenic and fas transgenic lpr mice.

doi:10.3109/08830189409051178

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Article

Apoptosis defects analyzed in TcR transgenic and fas transgenic lpr mice.

International reviews of immunology - 1 Jan 1994

Mountz J D, Zhou T, Bluethmann H, Wu J, Edwards C K

Abstract excerpt

Although autoreactive T cells are thought to play a prominent role in autoimmune disease in MRL-lpr/lpr mice, it has been difficult to directly determine if autoreactive T cells escape from the thymus and react with self-antigens in the periphery. Defective expression of the Fas apoptosis antigen...

Topics

Animals
Antigens, Surface
Apoptosis
Autoimmune Diseases
Female
Lymphocyte Activation
Male
Mice
Mice, Mutant Strains
Mice, Transgenic
Mutation
Receptors, Antigen, T-Cell
Retroelements
Self Tolerance
T-Lymphocytes
fas Receptor

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