Article
Lethal effect of the anti-Fas antibody in mice.
Nature - 26 Aug 1993
Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S
Abstract excerpt
During mammalian development, many cells are programmed to die most mediated by apoptosis. The Fas antigen coded by the structural gene for mouse lymphoproliferation mutation (lpr), is a cell surface protein belonging to the tumour necrosis factor/nerve growth factor receptor family, and mediates...
Topics
- Animals
- Antibodies, Monoclonal
- Antigens, Surface
- Apoptosis
- Blood
- Cell Line
- Cricetinae
- Female
- Humans
- Hybrid Cells
- Liver
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mutation
- Myocardium
- Phagocytosis
- Thymus Gland