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Article

Lethal effect of the anti-Fas antibody in mice.

Nature - 26 Aug 1993

Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S

Abstract excerpt

During mammalian development, many cells are programmed to die most mediated by apoptosis. The Fas antigen coded by the structural gene for mouse lymphoproliferation mutation (lpr), is a cell surface protein belonging to the tumour necrosis factor/nerve growth factor receptor family, and mediates apoptosis. The Fas antigen messenger RNA is expressed in the thymus, liver, heart, lung and ovary. We prepared a...

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Identifiers

PMID: 7689176
DOI: 10.1038/364806a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lethal effect of the anti-Fas antibody in mice.PMID 7689176Read ↗

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver.Semantic proximity Read ↗

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosisSemantic proximity Read ↗

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.Semantic proximity Read ↗

FasL deficiency enhances the development of tumors in p53+/- mice.Semantic proximity Read ↗

Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model.Semantic proximity Read ↗

A new alternative splice variant of the mouse Fas antigen with a deletion in the N-terminal portion of the extracellular domain.Semantic proximity Read ↗

Immunological and pathological consequences of mutations in both Fas and Fas ligand.Semantic proximity Read ↗

Expression of Fas in B cells of the mouse germinal center and Fas-dependent killing of activated B cells.Semantic proximity Read ↗

Mutations in the Fas antigen gene in lpr mice.Semantic proximity Read ↗

Pillars article: lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. 1992.Semantic proximity Read ↗

Lupus in the Fas lane?Semantic proximity Read ↗

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