p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.

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Article

p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.

Cancer research - 1 Nov 1994

Cheng J Q, Jhanwar S C, Klein W M, Bell D W, Lee W C, Altomare D A, Nobori T, Olopade O I, Buckler A J, Testa J R

Abstract excerpt

To determine whether p16 is altered in human malignant mesothelioma (MM), molecular analysis of multiple 9p loci was performed on 40 cell lines and 23 primary tumors from 42 MM patients. We identified homozygous deletions of p16 in 34 (85%) cell lines and a point mutation in 1 line. Down-regulation of p16 was observed in 4 of the remaining cell lines, 1 of which displayed a DNA rearrangement of p16. Homozygous...

Topics

Base Sequence
Carrier Proteins
Chromosome Mapping
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p16
DNA Probes
Down-Regulation
Gene Deletion
Genes, Tumor Suppressor
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mesothelioma

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

RNA, Messenger

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7923195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7923195-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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