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Article

Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.

Oncogene - 3 Aug 1995

Li Y J, Hoang-Xuan K, Delattre J Y, Poisson M, Thomas G, Hamelin R

Abstract excerpt

Four cyclin-dependent kinase inhibitors called p15, p16, p21 and p27 have been identified in mammals. Because these proteins participate in the control of cell cycle, they are potential targets for somatic mutations during carcinogenesis. In order to document the prevalence of p15 and p16 alterations in gliomas, we looked for loss of heterozygosity of chromosome 9p where these genes are localized. Allelic losses...

Topics

Base Sequence
Carrier Proteins
Cell Cycle Proteins
Chromosome Aberrations
Chromosome Deletion
Chromosome Disorders
Chromosome Mapping
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cyclins

DNA Primers

Glioma

Humans

Molecular Sequence Data

Mutation

Protein Kinase Inhibitors

Tumor Suppressor Proteins

Source

Identifiers

PMID: 7630644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7630644-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Frequent loss of heterozygosity on chromosome 9, and low incidence of mutations of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas.PMID 7630644Read ↗

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