Article
Restriction of the T-cell receptor V delta gene repertoire is due to preferential rearrangement and is independent of antigen selection.
Immunogenetics - 1 Jan 1995
Migone N, Padovan S, Zappador C, Giachino C, Bottaro M, Matullo G, Carbonara C, Libero G D, Casorati G
Abstract excerpt
To determine whether the limited V gene usage by the T-cell receptor delta (TCRD) chain is dictated by preferential rearrangement or by antigen selection, we characterized and compared the TCRDV gene repertoire of the productive with that of the unproductive allele in 80 human TCRG/TCRD clones. S...
Topics
- Alleles
- Amino Acid Sequence
- Antigens
- Base Sequence
- Clone Cells
- DNA Primers
- Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
- Humans
- Intestines
- Molecular Sequence Data
- Receptors, Antigen, T-Cell, gamma-delta
- Thymus Gland