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Article

Allelic exclusion at the TCR delta locus and commitment to gamma delta lineage: different modalities apply to distinct human gamma delta subsets.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2004

Couedel Chrystelle, Lippert Eric, Bernardeau Karine, Bonneville Marc, Davodeau François

Abstract excerpt

Expression of a beta-chain, as a pre-TCR, in T cell precursors prevents further rearrangements on the alternate beta allele through a strict allelic exclusion process and enables precursors to undergo differentiation. However, whether allelic exclusion applies to the TCR delta locus is unknown and the role of the gamma delta TCR in gamma delta lineage commitment is still unclear. Through the analysis of the...

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Source

Identifiers

PMID: 15100297
DOI: 10.4049/jimmunol.172.9.5544

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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