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Article

Gene targeted DNA double-strand break induction by (125)I-labeled triplex-forming oligonucleotides is highly mutagenic following repair in human cells.

Nucleic acids research - 1 Nov 1999

Mezhevaya K, Winters T A, Neumann R D

Abstract excerpt

A parallel binding motif 16mer triplex-forming oligonucleotide (TFO) complementary to a polypurine-polypyrimidine target region near the 3'-end of the SupF gene of plasmid pSP189 was labeled with [5-(125)I]dCMP at position 15. Following triplex formation and decay accumulation, radiation-induced site-specific double-strand breaks (DSBs) were produced in the pSP189 SupF gene. Bulk damaged DNA and the isolated...

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Identifiers

PMID: 10518622
DOI: 10.1093/nar/27.21.4282
PMCID: PMC148705

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Source receipt: pubmed, retrieved 7 Sept 2026.

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