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The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2017

Saleh Amer F, Fellows Mick D, Ying Liming, Gooderham Nigel J, Priestley Catherine C

Abstract excerpt

Triplex forming oligonucleotides (TFOs) bind in the major groove of DNA duplex in a sequence-specific manner imparted by Hoogsteen hydrogen bonds. There have been several reports demonstrating the ability of guanine-rich TFOs to induce targeted mutagenesis on an exogenous plasmid or an endogenous chromosomal locus. In particular, a 30mer guanine-rich triplex forming oligonucleotide, AG30, optimally designed to...

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PMID: 27660205
DOI: 10.1093/toxsci/kfw179

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