Article
Isolation and preliminary characterisation of an X-ray-sensitive mammalian mutant cell line (WMXRS-1).
Mutation research - 1 May 1994
McKay M J, Mann G J, McDonald D A, Jones S, Kefford R F
Abstract excerpt
Mammalian cell lines that are sensitive to particular genotoxic agents have proved the most effective starting point for the cloning of human DNA-repair genes. After ethyl methanesulphonate mutagenesis of the parent murine fibroblast L-cell line, a new mammalian X-ray-sensitive cell line (WMXRS-1) was isolated. For selection of the mutant, a novel detection method was used: putative X-ray-sensitive clones were...
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