Isolation and preliminary characterisation of an X-ray-sensitive mammalian mutant cell line (WMXRS-1).

doi:10.1016/0921-8777(94)90070-1

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Article

Isolation and preliminary characterisation of an X-ray-sensitive mammalian mutant cell line (WMXRS-1).

Mutation research - 1 May 1994

McKay M J, Mann G J, McDonald D A, Jones S, Kefford R F

Abstract excerpt

Mammalian cell lines that are sensitive to particular genotoxic agents have proved the most effective starting point for the cloning of human DNA-repair genes. After ethyl methanesulphonate mutagenesis of the parent murine fibroblast L-cell line, a new mammalian X-ray-sensitive cell line (WMXRS-1...

Topics

Animals
Bleomycin
Cell Cycle
Cell Line
Cell Survival
Cisplatin
DNA
DNA Damage
DNA Repair
Ethyl Methanesulfonate
Fibroblasts
Hydrogen Peroxide
Mice
Micronucleus Tests
Mitomycin
Mutagenesis
Mutation
Radiation Tolerance

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