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Kinds of mutations found when a shuttle vector containing adducts of 1,6-dinitropyrene replicates in human cells.

Carcinogenesis - 1 Jan 1991

Boldt J, Mah M C, Wang Y C, Smith B A, Beland F A, Maher V M, McCormick J J

Abstract excerpt

To gain insight into the mechanisms by which carcinogens induce mutations in human cells, we have been comparing the frequency and spectrum of mutations induced when a shuttle vector, pS189, carrying covalently bound residues of structurally related carcinogens, replicates in human 293 cells. In the present study, we investigated the mutagenic effects of N-hydroxy-1-amino-6-nitropyrene, a partially reduced...

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PMID: 1988171
DOI: 10.1093/carcin/12.1.119

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