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Article

Unambiguous demonstration of triple-helix-directed gene modification.

Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2000

Barre F X, Ait-Si-Ali S, Giovannangeli C, Luis R, Robin P, Pritchard L L, Helene C, Harel-Bellan A

Abstract excerpt

Triple-helix-forming oligonucleotides (TFOs), which can potentially modify target genes irreversibly, represent promising tools for antiviral therapies. However, their effectiveness on endogenous genes has yet to be unambiguously demonstrated. To monitor endogenous gene modification by TFOs in a yeast model, we inactivated an auxotrophic marker gene by inserting target sequences of interest into its coding...

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Identifiers

PMID: 10716704
DOI: 10.1073/pnas.97.7.3084
PMCID: PMC16196

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