Article
Passage of X-ray-induced immortal, non-transformed phenotype by DNA-mediated transfection.
Cancer letters - 20 Oct 1995
Too C K, Sierra-Rivera E, Oberley L W, Guernsey D L
Abstract excerpt
To better understand the molecular basis of X-ray-induced carcinogenesis, the immortalization step of this multistep process was examined. Primary rat embryo cells were X-irradiated in vitro and six clones were isolated. Three of these, one designated X-REF-23, were immortal and non-transformed. Transfection of high molecular weight DNA from rat X-REF-23 cells into primary mouse cells yielded two immortal and...
Topics
- Animals
- Cell Division
- DNA
- Mice
- Oncogenes
- Phenotype
- Rats
- Transfection
- X-Rays