Article
Effect of oncogene transfection or passage in vivo on malignant phenotypes of rat2 cells.
Anticancer research - 1 Jan 2000
Van Roy F M, Coopman P, Suffys P, Liebaut G, Vleminckx K, Gao J, Dragonetti C H, Fiers W, Mareel M M
Abstract excerpt
Rat2 cells are thymidine kinase-deficient derivatives from the immortalized rat embryo cell line Rat1. They show no phenotypic correlates of malignancy in vitro and produce tumors in syngeneic Fischer rats after long latency periods. We have investigated how transfection with oncogenes would alter the in vitro and in vivo behavior of Rat2 cells. Thus we have manipulated Rat2 cultures in various ways. The cell...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cosmids
- DNA
- Embryo, Mammalian
- Genes, ras
- Oncogenes
- Phenotype
- Rats
- Thymidine Kinase