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Article

Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens.

Carcinogenesis - 1 Feb 1995

Trott D A, Cuthbert A P, Overell R W, Russo I, Newbold R F

Abstract excerpt

Immortalization is a prerequisite for the clonal evolution and malignant transformation of normal mammalian cells in culture. In order to gain a mechanistic insight into the genetics of carcinogen-induced cellular immortality, a cell culture assay has been developed based on the use of freshly explanted Syrian hamster dermal (SHD) fibroblasts. The relative efficacies of a variety of chemical and physical...

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PMID: 7859348
DOI: 10.1093/carcin/16.2.193

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SHD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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