Article
Mechanisms involved in the immortalization of mammalian cells by ionizing radiation and chemical carcinogens.
Carcinogenesis - 1 Feb 1995
Trott D A, Cuthbert A P, Overell R W, Russo I, Newbold R F
Abstract excerpt
Immortalization is a prerequisite for the clonal evolution and malignant transformation of normal mammalian cells in culture. In order to gain a mechanistic insight into the genetics of carcinogen-induced cellular immortality, a cell culture assay has been developed based on the use of freshly ex...
Topics
- Animals
- Carcinogens
- Cell Transformation, Neoplastic
- Chromosomes
- Clone Cells
- Cricetinae
- Cricetulus
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Fibroblasts
- Gene Transfer Techniques
- Genes
- Humans
- Karyotyping
- Mesocricetus
- Mice
- Phenotype
- Rats