Multistep nature of X-ray-induced neoplastic transformation in mammalian cells: genetic alterations and instability.

doi:10.1269/jrr.38.55

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Article

Multistep nature of X-ray-induced neoplastic transformation in mammalian cells: genetic alterations and instability.

Journal of radiation research - 1 Mar 1997

Suzuki K

Abstract excerpt

X-ray-induced neoplastic transformation has been studied in Syrian hamster embryo cells. Unirradiated cells had a limited life span, whereas the irradiated cells escaped senescence, showed altered morphology, and acquired anchorage-independence and tumorigenicity in a stepwise manner during succe...

Topics

3T3 Cells
Animals
Cell Transformation, Neoplastic
Cocarcinogenesis
Cricetinae
Humans
In Vitro Techniques
Mice
Mutation
Oncogenes
Signal Transduction

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