Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule.

doi:10.1016/1074-7613(95)90128-0

Back to search

Article

Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule.

Immunity - 1 Nov 1995

Sun R, Shepherd S E, Geier S S, Thomson C T, Sheil J M, Nathenson S G

Abstract excerpt

Recognition of class I MHC antigens involves interaction between TCRs of cytotoxic T lymphocytes (CTL) and the two alpha helices of MHC molecules. Using a combined panel of H-2Kb mutants selected by either a CTL clone or MAbs, we have shown evidence that the TCRs of 59 Kb-specific CTL clones shar...

Topics

Animals
Cell Line, Transformed
Cytotoxicity Tests, Immunologic
H-2 Antigens
Mice
Mice, Inbred C57BL
Mutation
Receptors, Antigen, T-Cell
T-Lymphocytes, Cytotoxic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.