Article
Role of self-peptides in positively selecting the T-cell repertoire.
Nature - 1 Mar 1990
Nikolić-Zugić J, Bevan M J
Abstract excerpt
The fate of an immature thymocyte is determined by the specificity of its alpha beta T-cell receptor. Only cells expressing receptors that interact with sufficient affinity with major histocompatibility complex (MHC) molecules expressed on thymus epithelial cells are positively selected and go on to mature and seed the peripheral lymphoid organs. The H-2Kb class-I MHC molecule positively selects for the...
Topics
- Animals
- Antigen-Presenting Cells
- Female
- H-2 Antigens
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Ovalbumin
- Peptides
- Radiation Chimera