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Article

Role of self-peptides in positively selecting the T-cell repertoire.

Nature - 1 Mar 1990

Nikolić-Zugić J, Bevan M J

Abstract excerpt

The fate of an immature thymocyte is determined by the specificity of its alpha beta T-cell receptor. Only cells expressing receptors that interact with sufficient affinity with major histocompatibility complex (MHC) molecules expressed on thymus epithelial cells are positively selected and go on to mature and seed the peripheral lymphoid organs. The H-2Kb class-I MHC molecule positively selects for the...

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Identifiers

PMID: 2304556
DOI: 10.1038/344065a0

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Role of self-peptides in positively selecting the T-cell repertoire.PMID 2304556Read ↗

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Self-nonself discrimination by T cells.Semantic proximity Read ↗

T cell receptor interactions with class I heavy-chain influence T cell selection.Semantic proximity Read ↗

On the self-referential nature of naive MHC class II-restricted T cells.Semantic proximity Read ↗

Dynamics of positive and negative selection in the thymus: review and hypothesis.Semantic proximity Read ↗

A subset of CD4+ thymocytes selected by MHC class I molecules.Semantic proximity Read ↗

T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant LymphocytesSemantic proximity Read ↗

MHC molecules as peptide receptors.Semantic proximity Read ↗

Selecting and maintaining a diverse T-cell repertoire.Semantic proximity Read ↗

H-2 class I-restricted recognition of allogeneic class I peptides.Semantic proximity Read ↗

Pre–T cell receptors topologically sample self-ligands during thymocyte β-selectionSemantic proximity Read ↗

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