CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma.

doi:10.1093/intimm/4.4.455

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Article

CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma.

International immunology - 1 Apr 1992

Blok R, Margulies D H, Pease L, Ribaudo R K, Schneck J, McCluskey J

Abstract excerpt

The influence of CD8 on the fine specificity of MHC class I-restricted T cell allorecognition was evaluated by comparing the reactivity of CD8- and CD8-transfected forms of an allospecific, H-2Kb-restricted T hybridoma. The CD8- T hybridoma responded to cells expressing H-2Kb, H-2Kbm6, and the in...

Topics

Animals
Base Sequence
CD8 Antigens
DNA
H-2 Antigens
Hybridomas
Lymphocyte Activation
Mice
Molecular Sequence Data
Mutation
T-Lymphocytes
Transfection

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