Article
CD8 expression alters the fine specificity of an alloreactive MHC class I-specific T hybridoma.
International immunology - 1 Apr 1992
Blok R, Margulies D H, Pease L, Ribaudo R K, Schneck J, McCluskey J
Abstract excerpt
The influence of CD8 on the fine specificity of MHC class I-restricted T cell allorecognition was evaluated by comparing the reactivity of CD8- and CD8-transfected forms of an allospecific, H-2Kb-restricted T hybridoma. The CD8- T hybridoma responded to cells expressing H-2Kb, H-2Kbm6, and the individual H-2Kb----bm10 back mutations 165V----M, 173K----E, and 174N----L. Under the same conditions the CD8- T...
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