Article
Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects.
Pharmacogenetics - 1 Feb 2001
Vaziri S A, Hughes N C, Sampson H, Darlington G, Jewett M A, Grant D M
Abstract excerpt
Arylamines such as 2-naphthylamine and 4-aminobiphenyl are suspected human bladder procarcinogens that require bioactivation to DNA-reactive species to exert their carcinogenic potential. The goals of the present study were (i) to assay for the presence of the arylamine acetyltransferases NAT1 and NAT2, and of the cytochrome P450 isoform CYP1A2, in human bladder epithelium; and (ii) to determine whether the...
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