Article
Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer.
Journal of the National Cancer Institute - 21 Jul 1993
Bell D A, Taylor J A, Paulson D F, Robertson C N, Mohler J L, Lucier G W
Abstract excerpt
BACKGROUND: Numerous studies have associated bladder cancer with exposure to carcinogens present in tobacco smoke and other environmental or occupational exposures. Approximately 50% of all humans inherit two deleted copies of the GSTM1 gene which encodes for the carcinogen-detoxification enzyme...
Topics
- Base Sequence
- Carcinoma, Transitional Cell
- Female
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Humans
- Isoenzymes
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Racial Groups
- Smoking
- Urinary Bladder Neoplasms