Article
Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.
Environmental health perspectives - 1 Nov 1994
Daly A K, Cholerton S, Armstrong M, Idle J R
Abstract excerpt
Polymorphisms in many xenobiotic metabolizing enzymes occur leading to variation in the level of enzyme expression in vivo. Enzymes showing such polymorphisms include the cytochrome P450 enzymes CYP1A1, CYP1A2, CYP2A6, CYP2D6, and CYP2E1 and the phase two metabolism enzymes glutathione S-transferase MI (GSTMI) and arylamine N-acetyltransferase 2 (NAT2). In the past, these polymorphisms have been studied by...
Topics
- Animals
- Arylamine N-Acetyltransferase
- Cytochrome P-450 Enzyme System
- Genetic Predisposition to Disease
- Genotype
- Glutathione Transferase
- Humans
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length