Transgenic mice susceptible to poliovirus.

doi:10.1073/pnas.88.3.951

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Article

Transgenic mice susceptible to poliovirus.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1991

Koike S, Taya C, Kurata T, Abe S, Ise I, Yonekawa H, Nomoto A

Abstract excerpt

Poliovirus-sensitive transgenic mice were produced by introducing the human gene encoding cellular receptors for poliovirus into the mouse genome. Expression of the receptor mRNAs in tissues of the transgenic mice was analyzed by using RNA blot hybridization and the polymerase chain reaction. The human gene is expressed in many tissues of the transgenic mice just as in tissues of humans. The transgenic mice are...

Topics

Animals
Antigens, Viral
Cosmids
DNA
Genetic Predisposition to Disease
Genetic Vectors
HeLa Cells
Humans
Liver
Mice
Mice, Transgenic
Poliovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA, Messenger

Receptors, Virus

Restriction Mapping

Spinal Cord

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 1846972
DOI: 10.1073/pnas.88.3.951
PMCID: PMC50932

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1846972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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