Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster.

doi:10.1016/0925-4773(95)00379-7

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Article

Expression and targeting of Syrian hamster prion protein induced by heat shock in transgenic Drosophila melanogaster.

Mechanisms of development - 1 Jun 1995

Raeber A J, Muramoto T, Kornberg T B, Prusiner S B

Abstract excerpt

To evaluate the fruit fly as a model for studying neurodegenerative diseases caused by prions, transgenic flies were generated by introducing the Syrian hamster prion protein (SHaPrP) gene into the Drosophila melanogaster germ line by P element-mediated transformation. Nine transgenic lines were...

Topics

Animals
Animals, Genetically Modified
Cricetinae
Drosophila melanogaster
Gene Expression
Glycosylation
Heat-Shock Response
Mesocricetus
Mice
Mice, Transgenic
Models, Biological
Phenotype
Prions

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