Article
A transgenic mouse line developed to express human amyloidogenic transthyretin cDNA in the brain.
Biochemistry international - 1 Mar 1991
Ohuchi K, Matsuda A, Maeda S, Shimada K, Miyakawa T
Abstract excerpt
To elucidate the role of amyloid deposits in the pathogenesis of degenerative disorders of brain, we attempted to develop transgenic mice producing amyloidogenic human variant transthyretin (TTR) in the brain. A minigene, in which the promoter region of the mouse myelin basic protein (MBP) gene was ligated to the human mutant TTR cDNA, was used for microinjection. A transgenic mouse line expressing the human TTR...
Topics
- Amino Acid Sequence
- Amyloid beta-Peptides
- Animals
- Base Sequence
- Blotting, Southern
- Brain
- Electrophoresis, Agar Gel
- Gene Expression
- Humans
- L Cells
- Mice
- Mice, Transgenic