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Article

A transgenic mouse line developed to express human amyloidogenic transthyretin cDNA in the brain.

Biochemistry international - 1 Mar 1991

Ohuchi K, Matsuda A, Maeda S, Shimada K, Miyakawa T

Abstract excerpt

To elucidate the role of amyloid deposits in the pathogenesis of degenerative disorders of brain, we attempted to develop transgenic mice producing amyloidogenic human variant transthyretin (TTR) in the brain. A minigene, in which the promoter region of the mouse myelin basic protein (MBP) gene was ligated to the human mutant TTR cDNA, was used for microinjection. A transgenic mouse line expressing the human TTR...

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Identifiers

PMID: 1715703

Genes

TTR
MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A transgenic mouse line developed to express human amyloidogenic transthyretin cDNA in the brain.PMID 1715703Read ↗

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