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The PDAPP mouse model of Alzheimer's disease: Locus coeruleus neuronal shrinkage

14 Oct 2005

Abstract excerpt

Alzheimer's disease is characterized by neuronal degeneration in the cerebral cortex and hippocampus and subcortical neuronal degeneration in such nuclei as the locus coeruleus (LC). Transgenic mice overexpressing mutant human amyloid precursor protein V717F, PDAPP mice, develop several Alzheimer's disease-like lesions. The present study sought to determine whether there is also loss of LC noradrenergic neurons...

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PMID: 16228992
DOI: 10.1002/cne.20744

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