Multifactorial involvement of multidrug resistance-associated [correction of resistance] protein, DNA topoisomerase II and glutathione/glutathione-S-transferase in nonP-glycoprotein-mediated multidrug resistance in human bladder cancer cells.

doi:10.1111/j.1442-2042.1997.tb00314.x

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Article

Multifactorial involvement of multidrug resistance-associated [correction of resistance] protein, DNA topoisomerase II and glutathione/glutathione-S-transferase in nonP-glycoprotein-mediated multidrug resistance in human bladder cancer cells.

International journal of urology : official journal of the Japanese Urological Association - 1 Nov 1997

Kim W J, Kakehi Y, Yoshida O

Abstract excerpt

BACKGROUND: Multiple mechanisms are important in multidrug resistance in urothelial cancers. We investigated the acquisition of a multidrug resistance phenotype in human bladder cancer cells exposed to doxorubicin. METHODS: Human bladder cancer cell line 5637 and 2 doxorubicin drug-resistant subl...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
ATP-Binding Cassette Transporters
Antibiotics, Antineoplastic
Biomarkers, Tumor
DNA Primers
DNA Topoisomerases, Type II
Daunorubicin
Doxorubicin
Drug Resistance, Multiple
Glutathione
Glutathione Transferase
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Multidrug Resistance-Associated Proteins

Phenotype

Polymerase Chain Reaction

RNA, Messenger

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9477189
DOI: 10.1111/j.1442-2042.1997.tb00314.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9477189-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.