Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells.

doi:10.1038/bjc.1995.328

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Article

Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells.

British journal of cancer - 1 Aug 1995

Eijdems E W, Zaman G J, de Haas M, Versantvoort C H, Flens M J, Scheper R J, Kamst E, Borst P, Baas F

Abstract excerpt

We have analysed the contribution of several parameters, e.g. drug accumulation, MDR1 P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and topoisomerase (topo) II, to drug resistance in a large set of drug-resistant variants of the human non-small-cell lung cancer cell line SW-1573 derived by selection with low concentrations of doxorubicin or vincristine. Selection with either drug nearly...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
ATP-Binding Cassette Transporters
Antigens, Neoplasm
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
DNA Topoisomerases, Type II
DNA-Binding Proteins
Down-Regulation
Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression

Humans

Isoenzymes

Kinetics

Lung Neoplasms

Multidrug Resistance-Associated Proteins

Phenotype

RNA, Catalytic

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 7640209
DOI: 10.1038/bjc.1995.328
PMCID: PMC2033977

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7640209-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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