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Article

Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells.

British journal of cancer - 1 Aug 1995

Eijdems E W, Zaman G J, de Haas M, Versantvoort C H, Flens M J, Scheper R J, Kamst E, Borst P, Baas F

Abstract excerpt

We have analysed the contribution of several parameters, e.g. drug accumulation, MDR1 P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and topoisomerase (topo) II, to drug resistance in a large set of drug-resistant variants of the human non-small-cell lung cancer cell line SW-1573 derived by selection with low concentrations of doxorubicin or vincristine. Selection with either drug nearly...

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PMID: 7640209
DOI: 10.1038/bjc.1995.328
PMCID: PMC2033977

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