Article
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.
The Journal of biological chemistry - 20 Oct 1995
Ferguson S S, Ménard L, Barak L S, Koch W J, Colapietro A M, Caron M G
Abstract excerpt
The beta 2-adrenergic receptor (beta 2AR) belongs to the large family of G protein-coupled receptors. Mutation of tyrosine residue 326 to an alanine resulted in a beta 2AR mutant (beta 2AR-Y326A) that was defective in its ability to sequester and was less well coupled to adenylyl cyclase than the wild-type beta 2AR. However, this mutant receptor not only desensitized in response to agonist stimulation but...
Topics
- Adrenergic beta-Agonists
- Animals
- CHO Cells
- Cricetinae
- Cyclic AMP-Dependent Protein Kinases
- Mutation
- Phosphorylation
- Receptors, Adrenergic, beta-2
- beta-Adrenergic Receptor Kinases