Article
Mutations of Tyr326 in the beta 2-adrenoceptor disrupt multiple receptor functions.
European journal of pharmacology - 27 Jun 1996
Gabilondo A M, Krasel C, Lohse M J
Abstract excerpt
A tyrosine residue at the cytoplasmic end of the seventh transmembrane helix is conserved in many G-protein-coupled receptors. In the human beta 2-adrenoceptor, this tyrosine (Tyr326) has been proposed to be a specific determinant for agonist-induced receptor sequestration. In order to probe its...
Topics
- Adenylyl Cyclases
- Adrenergic beta-Agonists
- Adrenergic beta-Antagonists
- Alanine
- Animals
- CHO Cells
- Cell Membrane
- Cloning, Molecular
- Cricetinae
- Gene Expression
- Humans
- Iodine Radioisotopes
- Isoproterenol
- Mutagenesis, Site-Directed
- Mutation
- Phenylalanine
- Pindolol
- Protein Binding