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Article

Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.

Molecular pharmacology - 1 Jun 1990

Cheung A H, Dixon R A, Hill W S, Sigal I S, Strader C D

Abstract excerpt

The deletion of residues 222-229 from the hamster beta 2-adrenergic receptor (beta AR) resulted in an inability of the mutant receptor to couple to the guanine nucleotide-binding protein (G protein) Gs and to undergo the agonist-mediated sequestration response that is associated with desensitization [Mol. Pharmacol. 34:132-138 (1989)]. Replacement of this region of the beta AR with the analogous region of the...

Topics

Amino Acid Sequence
Animals
Binding, Competitive
Cell Membrane
Cells, Cultured
Cricetinae
GTP-Binding Proteins
Humans
Isoproterenol
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Adrenergic, beta

Signal Transduction

Structure-Activity Relationship

Source

Identifiers

PMID: 2163011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2163011-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.PMID 2163011Read ↗

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